Grandfatherhood

Genesis 48:5-6, 20 NLT 
“Now I am claiming as my own sons these two boys of yours, Ephraim and Manasseh, who were born here in the land of Egypt before I arrived. They will be my sons, just as Reuben and Simeon are. 6 But any children born to you in the future will be your own, and they will inherit land within the territories of their brothers Ephraim and Manasseh… 20 So Jacob blessed the boys that day with this blessing: “The people of Israel will use your names when they give a blessing. They will say, ‘May God make you as prosperous as Ephraim and Manasseh.’ ” In this way, Jacob put Ephraim ahead of Manasseh.

On his deathbed, Jacob blessed his most righteous son, Joseph, by “adopting” his two sons and equating their status with Joseph’s brothers. Ephraim and Manasseh would inherit from Jacob just as if they were his own sons - just like their uncles! Would we consider that fair? Jacob also broke with the normal way of doing things, and gave the younger Ephraim a more prominent place and blessing than he gave the elder Manasseh. Though Joseph was bothered by this, Jacob perceived something about the boys that prompted him to do this.

Is there any time to override family traditions and expectations of sibling equality in order to bless one grandchild over another - or two grandchildren over their parents, uncles, or aunts?

Should the character of grandchildren (or of the parents who train them up) factor into how proportionately we bless them?

Spiritually, emotionally, financially, or otherwise, how should you strive to apply the following proverb: 
Proverbs 13:22 NLT 
Good people leave an inheritance to their grandchildren, but the sinner’s wealth passes to the godly.